Its main properties. What is epigallocatechin gallate

Anti-cancer properties of the compound

Research suggests that green tea has the ability to protect the body against various types of cancer, including lung cancer, prostate cancer, and breast cancer. The reason for this, according to scientists, is epigallocatechin gallate contained in tea. According to the US National Cancer Institute, laboratory studies on animals have shown that this catechin deactivates oxidants before they can harm cells, reduces the number and size of tumors and inhibits the growth of cancer cells.

EGCG and breast cancer

EGCG and prostate cancer

In laboratory conditions, green tea catechins have been shown to inhibit the growth of cancer cells in prostate cancer. Dissolved in water, they reduced tumor development from 100% to 20% in a specially bred line of mice that spontaneously developed prostate cancer, Solway Pharma reports.

The study by Italian scientists involved men at high risk of developing prostate cancer. For 1 year, 30 men took 200 mg of green tea catechins 3 times a day. In the ninth month, in group 1, the PSA level decreased by 17%, which allowed us to conclude that tea catechins have a preventive effect on the development of prostate cancer.

EGCG and skin cancer

Epigallocatechin gallate helps protect the skin from the harmful effects of ultraviolet radiation and prevent the formation of tumors. In addition, it can combat the signs of skin aging.

Results are disputed

Tests conducted by the US Food and Drug Administration allowed her to challenge the claim that drinking green tea reduces the risk of breast and prostate cancer. It should be noted, however, that the subjects drank green tea rather than taking green tea extract or epigallocatechin gallate directly, so the dose of EGCG they consumed may have been lower than in the studies above.

EGCG and the brain

Reducing the risk of memory and attention disorders

The study found that older Japanese people who drank more than 2 cups of green tea per day had a 50% lower risk of memory and attention problems than those who drank less than 2 cups or other beverages studied. This effect is attributed to epigallocatechin gallate, which crosses the blood-brain barrier.

EGCG and Alzheimer's disease

Epigallocatechin gallate fights Alzheimer's disease, HealthDay News reports. Over the course of several months, laboratory mice were injected with EGCG, as a result of which 54% noticed a decrease in the formation of beta-amyloid formations blocking brain cells, which contribute to the development of Alzheimer's disease.

EGCG and HIV

Prof. M. Williamson states that "consumption of green tea can reduce the risk of contracting HIV, as well as slow the progression of the disease." . Although epigallocatechin gallate is neither a cure for HIV nor a guaranteed way to avoid infection, scientists recommend its use along with traditional remedies to improve the quality of life of those infected. The research is still in its early stages.

Japanese scientists explain the mechanism of action of EGCG: HIV infects CD4 T lymphocytes and uses the CD4 receptor at the molecular level to do this. As laboratory experiments show, by binding to the CD4 molecule, epigallocatechin gallate prevents the subsequent attachment of the HIV virus to it. The study found that EGCG binds to 80 percent of CD4 receptors within the first 5 minutes and binds to all of them after 30 minutes.

Now Foods, EGCg, Green Tea Extract, 400 mg, 180 Veggie Caps- green tea extract

Epigallocatechin Gallate - from the group of flavonoids, an organic substance, a polyphenolic compound with strong antioxidant properties. Contained in large quantities in tea. Mainly in white and green tea, and in black tea - in smaller quantities.

The effect of epigallocatechin gallate on cancer, multiple sclerosis, HIV infection, on brain activity, skin condition, etc. is currently being studied.

Research suggests that green tea has the ability to protect the body from various types of cancer, including lung cancer, prostate cancer and breast cancer. The reason for this, according to scientists, is epigallocatechin gallate contained in tea. According to the US National Cancer Institute, laboratory studies on animals have shown that it deactivates oxidants before they can harm cells, reduces the number and size of tumors and inhibits the growth of cancer cells.

Another study on carcinogenesis notes the ability of green tea in combination with tamoxifen to suppress the development of breast cancer in humans and mice.

In laboratory conditions, green tea catechins have been shown to inhibit the growth of cancer cells in prostate cancer. Dissolved in water, they reduced tumor development from 100% to 200% in a specially bred line of mice that spontaneously developed prostate cancer.

The study by Italian scientists involved men at high risk of developing prostate cancer. For 1 year, 30 men took 200 mg of green tea catechins 3 times a day. In the ninth month in group 1, the level of prostate specific antigen (PSA) decreased by 17%, which allowed us to conclude that tea catechins have a preventive effect on the development of prostate cancer.

Epigallocatechin gallate helps protect the skin from the harmful effects of ultraviolet radiation and prevent the formation of tumors. In addition, it can combat the signs of skin aging.

The study found that older Japanese people who drank more than 2 cups of green tea per day had a 50% lower risk of memory and attention problems than those who drank less than 2 cups or other beverages studied. This effect is attributed to epigallocatechin gallate, which crosses the blood-brain barrier.

Epigallocatechin gallate also fights Alzheimer's disease. Over the course of several months, laboratory mice were injected with EGCG, resulting in a 54% reduction in the formation of brain cell-blocking beta-amyloid formations, which contribute to the development of Alzheimer's disease.

EGCG in its pure form or green tea extract with 25% epigallocatechin gallate is often included in sports nutrition as a fat-burning component. Its effect is manifested in accelerating metabolism and increasing calorie consumption.

However, it would be fair to say that (at least as of 2015) the FDA (Food & Drug Administration) in the United States and the relevant agencies in Europe believed that the properties of epigallocatechin gallate in humans had not been conclusively confirmed.

200 mg of epigallocatechin gallate is contained in approximately 457 mg of catechin. Green tea extract contains only a certain percentage of catechins (in our case - 80%). Many manufacturers mislead consumers by indicating only the number of mg of extract. Some indicate catechin content. And only the most conscious manufacturers indicate the content of epigallocatechin gallate.

Therapeutic doses of epigallocatechin gallate used in clinical trials start at 200 mg and above.

When taking epigallocatechin gallate, increased sweating and increased body temperature are observed.

Latin name:—
ATX code: —
Active substance: Bioactive
phytocomponents
Manufacturer: MiraxBioPharma (RF)
Conditions for dispensing from a pharmacy: Over the counter

The dietary supplement Indinol + Epigallate is presented as a set of two separate drugs for simultaneous use in the treatment of endometriosis and other gynecological diseases.

Indications for use

Dietary supplements are used to replenish the deficiency of nutrients in the body. The combined action of the drugs has proven itself in the treatment of pathologies of the female reproductive system.

Indinol is indicated for:

• Any forms of fibrocystic mastopathy
• Infections of the genital organs caused by HPV
• Cervical dysplasia
• Leukoplakia of the female external genitalia
• Anogenital genital warts
• In tandem with Epigallate, the dietary supplement is used in the treatment of endometriosis, endometrial hyperplasia, and fibroids.

Epigallate (together with Indinol) helps with:

• Uterine fibroids, adenomyosis and their prevention after surgery
• Preventing recurrence of endometrial cysts after surgery
• Prevention of endometrial hyperplasia after abortion or RDV.

Composition of the drug

Contents of one Indinol capsule:

• Active ingredient – ​​100 mg indole-3-carbinol (from cruciferous plant extract)
• Auxiliary ingredients for filling the capsule and shell: lactose, starch, MCC, E572, water, gelatin.

Composition of one Epigallate capsule:

• Active component – ​​100 mg of green tea leaf extract, 50 mg of mineral premix (iron lactate, copper, iodine, zinc, manganese, selenium)
• Additional ingredients for filling and capsule body: milk sugar, aerosil, water, gelatin.

Medicinal properties

The dietary supplement Indinol + Epigallate is not a drug, but despite this, the effect of its use can be compared with the therapeutic one. This result was made possible due to the combined influence of the substances of the two drugs. Each of them has its own specific actions, as a result of which the desired effect is achieved.

• Indinol

A herbal product with antitumor and antiestrogenic properties. Its active component is indole-3-carbinol, the source of which is an extract from plants of the cruciferous family (primarily broccoli and other varieties of cabbage, as well as rutabaga, turnips, etc.). Reduces too high concentrations of estrogens, which contribute to the spread of the endometrium outside the uterine cavity and the attachment of tissue in uncharacteristic places.

Thanks to this, the substance has a good effect on the condition of the female reproductive system, eliminating endometriosis. Indinol also reduces the negative manifestations of PMS, helps with mastopathy, uterine fibroids, and ovarian cystosis. In addition, it has been proven that the herbal remedy protects against the occurrence or progression of cancer, the development of thrombosis, and has a positive effect on the cardiovascular system.

Herbal medicines based on indole-3-carbinol are also indicated for men in the treatment of prostate adenoma.

• Epigallate

A bioactive supplement, the effect of which is determined by the properties of a compound obtained from an extract of green tea leaves, one of the types of cahetin, - epigallocatechin-3-gallate. The substance has a healing effect on the female reproductive system in that it blocks abnormal cell division and growth in tissues and organs, reduces the invasiveness of endometrial cells, which ultimately leads to the elimination of endometrial lesions.

In addition, the active substance Epigallate stops abnormal vascular growth, thereby preventing the development of tumors. At the same time, it has an anti-inflammatory effect, blocking the functioning of cyclooxygenase, prostaglandins, and the formation of cytokines. At the same time, it enhances the effect of antibiotic drugs and increases the sensitivity of infectious agents to them.

Epigallate has a powerful antioxidant effect, suppressing the formation of free radicals, and enhances the effect of Indinol.

The combination of two dietary supplements turned out to be successful due not only to the individual properties of the components, but also to the mutual enhancement of each other’s actions.

Release forms

The drug is presented as a set of two separate dietary supplements. Both products are produced in capsule form:

• Indinol - in a two-color shell (white body and bright orange cap). Pill weight – 300 mg. The dietary supplement is packaged in plastic jars with a lid, containing 120 pieces.
• Epigallate – in the form of green capsules weighing 0.5 mg. Dietary supplement (120 pcs.) is packaged in a separate plastic jar.

Both products are placed in one cardboard package along with instructions for use.

Mode of application

Average cost of a set: 3600 rubles.

Before starting a course of dietary supplements, it is best to get the advice of a specialist. If he does not make other prescriptions, then the medications should be taken in accordance with the manufacturer’s recommendations.

You should take the capsules three times a day for 2-3 or more weeks. Single dosage for one dose – 1 Indinol pill and 1 pc. Epigallate. It is better to drink the product during meals.

The question of a repeat appointment must be agreed upon with the gynecologist.

During pregnancy and pregnancy

Not applicable.

Contraindications

Indinol + Epigallate, according to the instructions for use, should not be taken for:

• Individual hypersensitivity to the components of dietary supplements
• Pregnancy and breastfeeding
• Therapy with pharmaceuticals that reduce gastric acidity.

People with thyroid diseases should consult with an endocrinologist about the possibility of using a dietary supplement before taking Epigallate. Patients with problems digesting lactose should take into account that the capsules contain lactose.

Precautionary measures

The dietary supplement Indinol+Epigallate is not a medicine. Used in gynecology in combination with other medications prescribed by the attending doctor.

Cross-drug interactions

When Indinol + Epigallate is combined with antibiotics (tetracycline group or -lactams), the effect of the latter is enhanced.

Side effects

Basically, there are no complaints about the effect of Indinol + Epigallate. The effect of dietary supplements is well accepted by the body. Minor negative symptoms are usually temporary and therefore no specific treatment is required.

Possible negative manifestations:

• Change in duration (shortening or lengthening) of menstruation
• Stomach ache
• Slight decrease in thyroid hormones, FSH, prolactin, etc., increase in creatine concentration
• Individual reactions of the body
• Losing weight.

Epigallate:

• Individual allergies.

Overdose

The manufacturer has not reported the consequences of taking large quantities of Indinol + Epigallate capsules. It is assumed that manifestations of individual reactions of the body are possible.

Conditions and shelf life

Protect the set of dietary supplements from light and moisture; the temperature during storage should not exceed 25 °C. Restrict access to children! The validity period of dietary supplements is 2 years after the date of issue.

Analogues

There are no products that are absolutely similar in action and composition to Indinol + Epigallate. Only a physician can select another drug with the same therapeutic effect.

"Diode" (RF)

Average cost:(45 capsules) – 1005 rub.

In the dietary supplement, the same two active substances as in the first preparation are supplemented with a third component - soy isoflavones. The product is developed as an additional source of nutrients for gynecological problems. It has a beneficial effect on the female reproductive organs, normalizes estrogen levels, and reduces the threat of estrogen-dependent pathologies.

The product is produced in capsules of different colors (green, yellow, red). The manufacturer recommends drinking them one at a time throughout the day. If it is not possible to maintain a uniform interval, then it is recommended to take at least an hour break between doses so that the active components do not conflict with each other. The sequence of taking capsules is: yellow (in the morning) – green (in the middle of the day) – red (in the evening). It is better to drink the drug during meals.

Pros:

• Helps against mastopathy
• Reduces the size and number of ovarian cysts
• Natural composition.

Flaws:

• Doesn't help everyone
• High price.

MiraxBioPharma (RF)

Average cost of capsules:(60 pcs.) – 2640 rub.

Bioactive supplement containing indole carbinol. The product is used as an additional source of phytosubstance, as well as for the correction of hyperplastic processes occurring in the cells and tissues of the mammary gland.

The product is produced in capsules, which should be taken on an empty stomach, 2 pieces per day at equal intervals. The recommended course is for six months. If necessary, the issue of extending the course or repeating it is discussed with the treating specialist.

Dietary supplements can be taken by women over 18 years of age if there is no allergy to the constituent components, pregnancy or lactation. The drug contains lactose, which should be taken into account in patients with lactose intolerance, congenital lactase deficiency or glucose-galactose malabsorption.

The drug is usually perceived by the body normally. Possible side effects are temporary and go away without additional treatment. manifested by abdominal pain, changes in the circulatory system.

Pros:

• Natural composition
• Good result of therapy.

Flaws:

• High cost of treatment.

Vneshtorg Pharma (RF)

Price:(30 capsules) – 384-415 rub.

Bioactive complex based on several phytocomponents: extracts of vitex, dioscorea, soybean. Also contains boron, isoflavones, indolecarbinol and other components.

The herbal preparation is designed to replenish the reserves of missing substances in the body and eliminate conditions caused by their deficiency. Although the dietary supplement is not a hormonal drug, its actions are close to those of natural estrogen. The biological product helps reduce the manifestations of PMS and menopausal symptoms, normalizes the functioning of the genital organs, and has a beneficial effect on the nervous system.

Produced in capsule form. If there are no other prescriptions, then the dietary supplement should be taken according to the schedule suggested by the manufacturer: 1 or 2 pieces per day with meals. The recommended course is for two months.

Pros:

• Rich natural composition
• Helps against problems in the reproductive system.

Flaws:

• Specific smell
• May have a bad effect on hair condition.

Many of us know the beneficial properties of teas, but not everyone knows that the main active component in this product is epigallocatechin gallate, a polyphenolic compound from the group of flavonoids with a high antioxidant effect. What kind of substance is this and how justified is its use?

General characteristics of epigallocatechin gallate

The chemical formula of this unique compound is C 22 H 18 O 11. The highest concentration of the substance is concentrated in white and green teas, and only a small amount in black ones. Numerous scientific studies have shown that epigallocatechin gallate (EGCG, or green tea extract) is a powerful antioxidant that can neutralize free radicals before they interact with healthy cells, as well as inhibit the growth of cancer cells and reduce the size of pathological tumors. In this case, abnormal cells undergo a process of natural decay.

Note! One cup of properly prepared, high-quality green tea has the same amount of antioxidants as seven glasses of natural orange juice. People who regularly drink this drink significantly reduce the risk of developing dementia, as well as many types of cancer.

Benefits of Green Tea Extract

Epigallocatechin gallate, preventing the appearance and proliferation of new blood vessels, is an excellent preventive measure or inhibits pathologies such as endometriosis, adenomyosis, and uterine fibroids. This occurs due to the ability to restore the balance between cell growth and natural cell death.

Today, epigallocatechin-3-gallate is considered almost a panacea in dermatology and cosmetology. This is due to the following effects it produces on different layers of the skin:

• anti-inflammatory;
• wound healing;
• antimicrobial;
• antibacterial and antiviral;
• detoxifying;
• immunostimulating;
• regenerating;
• sunscreen;
• antioxidant;
• antitumor.

A drug for external use, Egallohit, was created based on EGCG. It comes in the form of a cream or gel and consists of 70% green tea extract. As a result of its use, patients experience accelerated healing of skin lesions without accompanying complications in the form of scars or scars, a reduction in the likelihood of consequences of cosmetic procedures, and an improvement in the appearance of the skin.

This is interesting! A representative of the Medical College of Georgia Department of Oral Biology, Doctor of Cell Biology Stephen Hsu, states that, despite the incomplete study of all the beneficial properties of epigallocatechin gallate, this substance can become a real “fountain of youth.”

With the help of the extract, in the future it will be possible to control dying skin cells, which will lead to a significant improvement in its condition.

In laboratory studies, the beneficial effects of green tea extract on cancer were noted:

1. Suppressing the development of breast cancer.
2. Inhibition of the growth of pathological cells in prostate cancer.
3. Protecting the skin from UV radiation and preventing the development of tumors on it.

Note! There are oncoprotective drugs, the main active components of which are epigallocatechin gallate. These drugs include Epigalin and Epigalin Brest.

Green tea extract has positively demonstrated its beneficial properties in other branches of medicine:

• reducing the risk of memory impairment, attention and concentration, especially in older people;
• blocking beta-amyloid formations, which, by affecting brain cells, contribute to the development of Alzheimer's disease;
• reducing the risk of infection or stopping the further development of HIV;
• acceleration of metabolic processes, which allows the successful use of EGCG in the manufacture of dietary supplements for sports nutrition.

Some foreign research institutes dispute certain properties of green tea extract. However, in fairness, it is worth noting that their subjects did not take epigallocatechin gallate, but simply drank green tea, the dosage of the active component in which is much lower compared to the extract.

Latest update of the description by the manufacturer 29.08.2011

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Nosological classification (ICD-10)

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Composition and release form

10 pcs in blister; in a package there are 3 blisters or in polymer jars of 60, 90 or 120 pcs.; It is allowed to pack the can in a consumer pack.

Characteristic

Biologically active food supplement.

Effect on the body

The active substances of Epigallate ® have multiple etiopathogenetic effects in relation to hyperplastic processes of the reproductive system. Suppress pathological growth and cell division in organs and tissues of the female reproductive system caused by non-hormonal stimuli. They reduce the invasive activity of endometrial cells and also cause selective death (apoptosis) of cells with increased proliferative activity. Epigallate ® has a pronounced antiangiogenic effect (suppresses the pathological growth of new vessels), etc. prevents the growth of tumors. It is an effective anti-inflammatory agent, suppressing the activity of COX-2, PG and the synthesis of pro-inflammatory cytokines, and in addition, enhances the effect of antibiotics (tetracyclines, beta-lactams) and increases the sensitivity of resistant microorganisms to the action of antibacterial agents. It has a pronounced antioxidant effect, neutralizing the formation of free radicals.

As an additional source of flavonoids (epigallocatechin-3-gallate) and minerals.

Epigallate ® is recommended in combination with the dietary supplement Indinol ® in the complex treatment of endometriosis, adenomyosis, uterine fibroids and endometrial hyperplasia without atypia, as well as for the prevention of relapses of these diseases after surgical treatment. It has a pronounced inhibitory effect on the recurrence of endometrioid ovarian cysts in the postoperative period.

Contraindications

Individual intolerance to dietary supplement components.

Side effects

According to preclinical and clinical studies, Epigallate ® is well tolerated, without causing side effects in therapeutic doses.

Directions for use and doses

Inside, while eating . Epigallate ® is prescribed 1 caps. 1 per day. Duration of treatment: 1 month. As a rule, it is recommended in combination with Indinol ® (1 cap. + 1 cap.). Longer use of the drug is possible on the recommendation of a doctor.

Storage conditions for the drug Epigallat ®

Keep out of the reach of children.

Shelf life of the drug Epigallat ®

Do not use after the expiration date stated on the package.