Treatment with Unidox Solutab tablets - instructions for use for ureaplasma, composition and analogues. Instructions for use of the antibiotic Unidox Solutab 10 active substance Unidox Solutab

Latin name: UNIDOX SOLUTAB
ATX code: J01AA02
Active substance: doxycycline
Manufacturer: Astellas(Netherlands)
Conditions for dispensing from a pharmacy: On prescription

Unidox Solutab tablets are an antibiotic that destroys RNA synthesis processes in some small organisms. The drug is active against gram-positive (various types of streptococcus) and gram-negative (bacillus and other organisms) aerobic bacteria.

Indications

• Should be taken if you have any type of STI - prostatitis, syphilis
• For acne on the face and body
• If relapsing fever is present
• Have Lyme disease
• Zoonotic infectious disorders of a bacterial nature
• Infections in the lower respiratory tract
• Infectious processes and diseases in the gastrointestinal tract - gastritis, cholera, dysentery
• After wound infections caused by animal bites
• Thyroid diseases after surgery
• For the treatment of chlamydia, cystitis
• Preventative measures to prevent the formation of diseases.

Compound

• In Unidox Solutab - 0.1 grams of doxycycline
• Excipients, saccharin, magnesium stearate and others.

Medicinal properties

The drug Unidox Solutab (tablets) actively affects bacteria, as a result of which they die. Absorption of the Unidox Solutab tablet occurs quickly and 100%. Food intake has a slight influence on the process, but has no clinical significance. The main active ingredient has a strong connection with plasma proteins by 80-90%, which contributes to its good penetration into tissues. The permeability into the spinal and cerebral fluid is quite weak, only 10-20%; if the spinal lining becomes inflamed, the absorption of the drug becomes greater. Penetration of the main active substance through the placental barrier is ensured. Also, some part of Unidox Solutab is excreted in breast milk.

Release form

Price from 300 rub.

The antibiotic is available in the form of dispersible tablets of 100 mg. Round shape with convexity on both sides. Color can vary, usually represented by various shades of yellow.

Dosage

Unidox Solutab is prescribed at 100 mg or 200 mg per day per 20 ml of water, it can be taken in 1 dose, or it can be divided into 2. Then the dose is halved and the dose is continued.

Mode of application

Dissolve the tablets in 20 ml of water and take after meals. Stir until a suspension is formed; you can drink it whole with water. For chlamydia and other diseases, treatment is prescribed by a doctor.

For Gonorrhea

In addition to anorectal infectious processes in men! For adults, a dosage of 100 mg, 200 mg per 20 ml of water is prescribed, 2 times a day, until the antibiotic completely eliminates the disease (on average, the duration of treatment is 7 days).

Unidox Solutab for acne

For acne, prescribe 100 mg per day after meals, diluted in 20 ml of water, depending on the condition of the skin.

Leptospirosis and chlamydia

The drug is used at a dose of 100 mg per 20 ml of water for a week after meals. Prescribe 100 or 200 mg per week, the antibiotic is diluted with 20 ml of water, especially during the period when a person is in a dangerous zone of infection.

For prostatitis

For prostatitis, take 100 or 200 mg per day for a month. The daily dose is divided into two doses, the interval between them should be 12 hours, a course of 7 days to 10 days is prescribed. You can also take doxycycline monohydrate for prostatitis.

Eye diseases

100 or 200 mg is divided into two doses, and the antibiotic is prescribed with 20 ml of water each time, from 10 days.

During pregnancy and lactation

The use of Doxycycline or Unidox is contraindicated.

Contraindications

• Children under 8 years old
• During pregnancy and breastfeeding
• Severe liver pathologies.

Precautionary measures

The drug Unidox Solutab is prescribed orally. It is better to take the tablet with plenty of clean water at room temperature, the recommended position is standing. Sunbathing is not recommended during treatment. Caution is required in use for people with renal failure. Hypovitaminosis may be caused, so you should drink the drug exclusively during or after meals. If you have chlamydia, you should consult your doctor before using Unidox Solutab.

Cross-drug interactions

Products that contain active elements help reduce the absorption of the main substance of the drug, so they should be used at intervals of 3 hours. When the active substance is combined with antibiotics, cell wall synthesis is disrupted, resulting in a decrease in the effectiveness of the drug. When used together with oral contraceptives, the effect of the latter drugs is reduced, and acyclic bleeding may occur. Ethanol-based products accelerate metabolism and reduce the concentration of the substance in the blood plasma. Intracranial pressure may increase.

Side effects

• Vomiting, mild nausea, loss of appetite, enterocolitis
• Urticaria, dermatitis, erythema, pericarditis
• The occurrence of hallucinations such as tinnitus
• Anemia and thrombocytopenia
• Brittle teeth, nails, changes in enamel
• Anaphylactic shock, difficulty breathing.

Overdose

Possible headache, nausea and vomiting. If symptoms are detected and an overdose is suspected, urgent gastric lavage is performed. It is recommended to drink as much fluid as possible, you can take laxatives and activated carbon, which is an excellent adsorbent. In case of overdose, yellowing of the skin may occur.

Conditions and storage period

The drug is stored in a cool, dark place at a temperature of +15 to +25C away from children. Shelf life is 5 years from the date of manufacture of the drug. Must be discarded after expiration date.

Analogues

Manufacturer: Tarkhomisky Pharmaceutical Plant "POLFA" JSC, Russia.
Price– from 300 rubles.
A drug that has an antibacterial effect and has a wide spectrum of action. Promotes inhibition of protein biosynthesis, which occurs at the ribosomal level. Actively affects all types of bacteria.
Pros:

• Better effect on intestinal flora
• Lasts longer after use
• Fully absorbed
• Effective against chlamydia
• Can dissolve in lipids.

Minuses:

• Many contraindications
• Possible side effects when using
• Requires a doctor's prescription.

Doxy-M

Manufacturer: Merkle GmbH, Germany.
Price- 500 rubles.
DOXY-M is an antimicrobial drug belonging to the tetracycline group. It contains Dixycycline as an active substance, which is a broad-spectrum antibiotic. Promotes disruption of protein synthesis in the cells of microorganisms that infect the human body. Taken for chlamydia and prostatitis. Take with food for 5-10 days.
Pros:

• The drug is effective after illnesses
• The drug is quickly absorbed.

Minuses:

• High price
• There are many contraindications.

Vilprafen

Manufacturer: YAMANOUCHI PHARMA, Germany.
Price– from 500 rubles per package.
Vilprafen actively fights microbes, stopping the possibility of protein synthesis in affected cells. Slows down the growth and prevents the proliferation of bacteria. The antibiotic Vilprafen has josamycin as its main substance, which is well absorbed and actively excreted naturally. Vilprafen is used for infectious and inflammatory diseases of any type, actively affecting bacteria. Should be taken with meals for several days.
Pros:

• Vilprafen is prescribed for chlamydia, prostatitis and other infections
• Quickly acts on lesions
• Vilprafen has a wide range of effects.

Minuses:

• High price
• Lots of side effects.

Manufacturer: LLC Pharmaceutical Company Health, Ukraine.
Price– 20-100 rubles for 10 tablets.
Antibiotic Metronidazole is an antibacterial agent that provides biochemical reduction of the nitro group through intracellular proteins. Metronidazole affects anaerobic and protozoan substances, suppressing protein synthesis in their structure. Drink during meals for 7 days.
Pros:

• Metronidazole is 100% effective against a wide range of diseases (chlamydia and others)
• The medicine has a low cost
• Antibiotic cures many diseases
• Can be drunk for 7 days.

Minuses:

• There are many contraindications and side effects after taking it.

The drug Unidox Solutab is an antibiotic agent of the tetracycline group with a wide spectrum of antimicrobial effects. The medication is applicable for the treatment of many infectious lesions of various body systems caused by pathogenic microorganisms sensitive to the action of the active component. The product has a pronounced bacteriostatic effect. Unidox Solutab can be taken from 8 years of age, which significantly expands the therapeutic capabilities of the drug. To achieve the most effective result, you should entrust the calculation of individual dosages to a qualified specialist.

Dosage form

The antimicrobial agent Unidox Solutab is available in the form of round grayish-yellow biconvex dispersible tablets with the engraved code “173” on one side and a notched dividing strip on the other.

The medication is packaged in cardboard packs containing one blister of 10 tablets.

Description and composition

The active ingredient of the antibiotic Unidox Solutab is represented by monohydrate. Each medicinal unit contains 100 mg of the active element.

The excipients are:

• anhydrous silica;
• magnesium stearate;
• hypromellose;
• lactose monohydrate;
• saccharin;
• microcrystalline cellulose.

Pharmacological group

Unidox Solutab belongs to the group of tetracycline antimicrobial drugs with a pronounced bacteriostatic effect. Drug activity consists of disrupting metabolic processes and interrupting protein synthesis in the cell membranes of pathogenic microorganisms. In addition, the substance helps break the bonds of certain types of RNA with ribosomal membranes. exhibits increased activity against developing and dividing bacteria. The product has virtually no effect on microflora that are at rest. The bacteriostatic effect is observed against a wide range of pathogenic microorganisms. Some gram-positive, gram-negative and various bacteria that cause sexually transmitted infections are susceptible to the action.

Unidox Solutab exhibits a high degree of absorption from the gastrointestinal tract, which is not affected by food intake. The possibility of binding to serum proteins averages 90%. The concentration of the active substance in plasma reaches a maximum 2–3 hours after oral administration.

Hepatic metabolism produces both active and inactive metabolites. Excretion of active metabolic products in unchanged form occurs in the urine, while inactive metabolites are excreted in feces. The half-life is 16 to 18 hours. When taking the medicine again, this time increases by 3–4 hours.

The active substance of Unidox Solutab can penetrate the placental barrier and enter breast milk. The medication accumulates in the tissues of the prostate gland.

Indications for use

The drug is prescribed for the treatment of infectious diseases caused by a wide range of pathogenic microorganisms susceptible to the action.

for adults

Infections of the gastrointestinal tract and biliary tract:

• traveler's diarrhea;
• cholera;
• cholecystitis;
• amoebic dysentery;
• cholangitis;
• gastroenterocolitis.

Infections of the genitourinary system:

• urethritis;
• chlamydia;
• syphilis;
• gonorrhea (as an alternative treatment);
• lymphogranuloma of a venereal nature;
• urogenital mycoplasmosis;
• prostatitis of a bacterial nature.

ENT infections:

• sinusitis;
• tonsillitis.

Other infections:

• acute degree of infectious;
• malaria;
• severe form of acne;
• infectious lesions after animal bites;
• plague;
• peritonitis;
• whooping cough;
• lung abscess;
• actinomycosis;
• eye infections;
• sepsis.

for children

Children under the age of 8 years are prohibited from using Unidox Solutab due to the extremely negative effect of the active element of the drug on the growth and development of the child’s skeletal bones and teeth.

The medication may pass into breast milk. If it is necessary to use the drug during lactation, it is necessary to stop breastfeeding.

During pregnancy, the use of the product is strictly prohibited due to the possibility of passing through the placenta.

Contraindications

• age group of patients up to 8 years;
• pregnancy and GC period;
• acute form of renal and/or liver failure;
• increased sensitivity of the patient's body to tetracyclines.

Applications and dosages

For the fastest and most effective achievement of therapeutic goals, it is recommended to draw up the average daily dosage and medication regimen together with your doctor.

The tablets can be taken either whole or crushed. You should drink the product with plenty of clean water.

for adults

Adult patients and children over 8 years of age whose body weight exceeds 50 kg are prescribed an initial dose of Unidox Solutab at a dosage of 100 mg 2 times a day or 200 mg 1 time a day. From the second day until the end of the course, the average daily dose should be 100 mg. For severe types of diseases, the initial dosage remains unchanged.

for children

The use of the drug for children under 8 years of age is strictly contraindicated.

For the age group over 8 years old, with a body weight of no more than 50 kg, it is recommended to take the medication in the following dosages:

• on the first day, the dose should be 4 mg for each kg of the child’s weight;
• the following doses of medication are 2 mg per kg of weight.

In the case of severe infectious pathologies, the initial dosage does not change throughout the entire therapeutic course.

for pregnant women and during lactation

The use of this medication is contraindicated for pregnant and lactating women. If it is necessary to use it during breastfeeding, you should immediately stop feeding the baby breast milk.

Side effects

• decrease in prothrombin time;
• nausea;
• development of candidiasis diseases;
• various stool disorders;
• dermatitis;
• thrombocytopenia;
• inflammation of the tongue;
• increased intracranial pressure;
• the appearance of an itchy rash on the skin;
• dizziness;
• enterocolitis;
• increased sensitivity to ultraviolet or visible radiation;
• Quincke's edema;
• anemia.

Interaction with other drugs

The use of Unidox Solutab in combination with cephalosporins, penicillin antibiotics and other drugs that have a bactericidal effect is contraindicated.

It is also undesirable to use it simultaneously with antacids and other metal-containing drugs due to the possibility of the formation of inactive compounds due to a chemical reaction.

The prothrombin index may change when used together with anticoagulants.

Colestipol and cholestyramine reduce the absorption of the drug.

When taken simultaneously with retinol, a significant increase in intracranial pressure is possible.

The medication reduces the effectiveness of oral contraceptives and increases the frequency of uterine bleeding that occurs due to their use.

special instructions

If the patient has various renal dysfunctions, no additional adjustments to drug dosages are required.

The medication can cause underdevelopment of tooth enamel and significantly slow down the longitudinal growth of skeletal bones in children under 8 years of age.

In case of liver diseases, special care must be taken.

To prevent the irritating effect of the drug on the mucous membranes of the gastrointestinal tract, it is recommended to take the drug in the middle of the day with a sufficient amount of liquid.

Overdose

Symptoms of overdose with increased doses of Unidox Solutab are:

• diarrhea;
• seizures;
• anorexia;
• feeling dizzy;
• nausea;
• pain in the head.

If signs of intoxication occur, you must immediately take a sufficient amount of enterosorbents, rinse the stomach and begin symptomatic treatment.

Analogues

Instead of Unidox Solutab, the following drugs can be used:

1. - a domestic drug that is produced by a number of Russian companies. It is available for sale in capsules (allowed for patients over 12 years of age, whose weight is more than 45 kg) and lyophilisate from which an infusion solution is prepared (available from 8 years of age). The antibiotic is contraindicated in pregnant and lactating women.
2. Xedocin is a German drug that is a complete analogue of the drug Unidox Solutab. The antibiotic is produced in capsules, which are contraindicated in children under 8 years of age, pregnant women and breastfeeding women.
3. Vidoccin is a domestic medicine based on , which is produced in a lyophilisate and when diluted, a solution for intravenous administration is obtained. The medicine is prohibited for children under 8 years of age, pregnant and lactating women.
4. Minolexin is a substitute for the drug Unidox Solutab according to the pharmacological group. The antibiotic is produced in capsules, approved for children over 8 years of age and pregnant patients. It is recommended to interrupt breastfeeding while taking the medication.

Storage conditions

The medication should be stored in a dry, dark place at a temperature not exceeding 25 degrees. It is necessary to limit children's access to the drug.

Shelf life – 5 years.

Drug price

The cost of the medicine is on average 322 rubles. Prices range from 283 to 367 rubles.

How to take Unidox Solutab for ureaplasma - this question often worries patients. Unidox Solutab is an antibiotic belonging to the tetracycline group. Most often it is used in the treatment of various kinds of infectious diseases. It may well be prescribed for genital ureaplasma parvum.

Action of the antibiotic

This disease most often affects those who have been diagnosed with infertility or those who constantly suffer from inflammatory diseases of the genital organs, since ureaplasma is a specific bacteria that causes inflammation. They infect the urinary and reproductive systems.

According to statistics, almost 70% of men and women on the planet have ureaplasma in their bodies. But most often it affects women. Also at risk are people with weak immune systems and those infected with HIV.

The drug is produced in the Netherlands on the basis of the Astellas concern. The product is available in the form of yellow-white or yellow-gray tablets. One side is marked "173". Each tablet contains 100 mg of active ingredient. There are 10 tablets in one package.

How is Unidox Solutab treated? This antibiotic is quite strong, so when prescribing it, the doctor must remember the individual characteristics of the patient, the presence or absence of pathogens of other infectious diseases, as well as allergies to tetracycline antibiotics. You cannot prescribe or drink the drug yourself.

If all factors are taken into account, it will be much easier to treat the patient. The dosage of the drug and the duration of treatment are prescribed by the doctor depending on the nature of the disease. The effect appears soon after the start of therapy.

How to take Unidox Solutab?

The drug can be consumed either in solid form with water or dissolved in water. The manufacturer believes that in both forms it will work effectively and is quickly absorbed into the body.

Stages of treatment:

1. For ureaplasmosis, the duration of treatment can be 7 days. This is quite enough for a complete recovery.
2. Treatment continues only if there are any complications.
3. After 7–8 days of treatment, the patient is prescribed a second dose. This is necessary in order to understand whether the antibiotic is effective. If no qualitative improvement is observed, then the antibiotic is changed.

Doctors note that there are no pronounced side effects when treating ureaplasmosis with Unidox Salutab. Diarrhea is possible, but if it occurs, doctors should immediately change the antibiotic.

Only in exceptional cases, when there are several concomitant infections, or when the patient’s immune system is extremely weak, is Unidox Salutab ineffective for ureaplasma. In such cases, doctors usually change the antibiotics and prescribe a longer course of treatment.

During treatment, both partners must take the drug according to the same regimen.

The drug does not have a serious effect on kidney function, so it can be prescribed to patients with renal failure.

Both partners are prescribed a high-calorie diet. The only absolute contraindication for nutrition is the consumption of milk and dairy products, since the drug, when reacting with them, forms insoluble compounds - chelates, which reduce the effects of the antibiotic.

It should be noted that the drug can be taken both on a full and empty stomach. This does not reduce the efficiency of its work.

special instructions

Antibiotic treatment and alcohol consumption are incompatible. After completing the course of treatment, you must abstain from strong drinks for at least another week. This time is necessary for the substance to be completely eliminated from the body.

Doctors do not recommend taking other tablets with a high iron content and antibiotics containing doxycycline (the main active ingredient of the drug, which prevents the development and spread of pathogenic bacteria) during treatment with these drugs.

What is prescribed additionally?

Another mandatory point is comprehensive treatment. During the period of taking the drug Unidox Solutab for ureaplasma, the following are prescribed:

1. Probiotics are prescribed because antibiotics of any group negatively affect the microflora of the gastrointestinal tract, although the composition of the drug is such that irritation of the gastric mucosa does not occur, since doxycycline is present in it in the form of monohydrate with water, and that is why it is absorbed in the intestines.

After completing the course of treatment and undergoing examination, the patient is considered healthy. But many doctors recommend prescribing the patient a repeat preventative examination 2-3 months after the end of the course of treatment. This is due to the fact that genital ureaplasmosis is a recurrent disease.

Contraindications

A categorical contraindication for taking the drug is pregnancy and lactation, since the main active substance can penetrate the placental barrier and have a negative effect on the fetus; it also accumulates in breast milk, which is harmful to the child.

The drug is never prescribed to children under 8 years of age. With kidney and liver dysfunction, there may be contraindications for use. The period of complete elimination of the drug from the body is from 17 to 23 hours.

For infectious diseases, doctors often prescribe the new generation antibiotic Unidox. The instructions recommend using this remedy for inflammatory processes caused by various microorganisms. The drug belongs to the group of tetracyclines and is able to act on a wide range of pathogens. The medicine not only destroys bacteria, but also prevents their further reproduction.

What is included in the tablets?

The active component of the drug "Unidox" is the tetracycline antibiotic doxycycline. Each tablet contains 100 mg of this substance, which is what has an antibacterial effect on the body.

The medicine also contains additional components: magnesium stearate, microcrystalline cellulose, hyprolose, lactose monohydrate, colloidal silicon dioxide. These substances do not have a therapeutic effect, but contribute to better absorption of doxycycline.

The medicine is released only in tablet form. In the pharmacy chain you can find the drugs "Unidox" and "Unidox Solutab". The only difference is that Unidox Solutab tablets can be crushed, dissolved in water and prepared as a suspension. This form is convenient when treating children. In all other respects, these drugs are absolutely identical.

The medicine looks like round tablets, convex on both sides. The number 173 is engraved on them - this is the drug code.

How does an antibiotic work?

The medicine affects microorganisms at the cellular level. Doxycycline affects the RNA of harmful bacteria and inhibits the formation of microbial proteins. It is effective against many gram-positive and gram-negative bacteria: streptococci, staphylococci, treponemas, salmonella, pathogens of many intestinal and genitourinary infections. In addition, it is capable of destroying some protozoan microorganisms - dysentery amoeba and plasmodium (the causative agent of malaria).

However, for some infections there will be no effect from using Unidox. The instructions say that doxycycline does not affect all types of viral and fungal microorganisms, as well as Proteus, enterococci and Pseudomonas aeruginosa.

"Unidox" does not adversely affect the natural microflora of the digestive system and does not reduce immunity.

For what diseases is the drug prescribed?

If a patient is diagnosed with an infectious disease, the causative agent of which is susceptible to the effects of doxycycline, then the doctor may prescribe Unidox tablets. The use of antibiotics is indicated for the following pathologies:

• otolaryngeal infectious diseases (otitis media, sinusitis, sinusitis, tonsillitis, laryngitis, nasopharyngitis);
• respiratory pathologies caused by bacteria: bronchitis, pneumonia, tracheitis, lung abscess;
• gastrointestinal infections: gastroenteritis, cholecystitis, cholangitis, bacterial and yersiniosis;
• sexually transmitted diseases: syphilis, gonorrhea, chlamydia, inguinal and venereal granuloma;
• eye damage from chlamydial infection (trachoma);
• tick-borne;
• whooping cough;
• sepsis;
• osteomyelitis;
• brucellosis;
• skin infections, acne;
• after operations to prevent purulent infection;
• genitourinary cystitis, urethritis, endometritis, prostatitis, cervicitis, salpingoophoritis.

These are the most common indications for prescribing the Unidox antibiotic. In addition, the drug is effective against particularly dangerous infections and imported tropical diseases, such as:

• cholera;
• typhus (abdominal, typhus and relapsing);
• plague;
• malaria;
• legionellosis;
• Q fever;
• yaws;
• leptospirosis;
• Rocky Mountain spotted fever.

In some cases, it is possible to use Unidox tablets for preventive purposes. The instructions recommend prescribing the drug to people traveling to tropical countries to prevent infection with malaria and leptospirosis.

When is the medicine contraindicated?

However, such an effective antibiotic as Unidox is not suitable for all groups of patients. First of all, it should not be taken by people with hypersensitivity to doxycycline and the auxiliary components of the tablets. It should not be used by patients who have previously been allergic to tetracycline medications.

There are other cases when the drug is strictly contraindicated. Unidox tablets should not be taken by pregnant or nursing mothers. Doxycycline is able to overcome and also pass into breast milk. If a woman needs to undergo treatment during lactation, then breastfeeding should be stopped. This antibiotic is not prescribed to children under 8 years of age. Contraindications are due to the fact that doxycycline can accumulate in the bones and lead to calcium deposits in the skeleton of the fetus and small child. In addition, the drug can negatively affect the formation of teeth in children under 8 years of age.

Medicines containing doxycycline are contraindicated in patients with severe pathologies of the liver and kidneys and in patients diagnosed with porphyria.

Undesirable effects of the drug

The body of some patients may react negatively to taking Unidox. Side effects may occur from the following organs and systems:

1. Central nervous system. May cause headache, intracranial hypertension, dizziness.
2. Gastrointestinal tract. Sometimes dyspeptic symptoms appear: nausea, vomiting, intestinal disorders, loss of appetite, and some patients experience symptoms of anorexia.
3. Skin. Dermatitis, rashes, and hyperemia occur. Photosensitivity of the skin increases.
4. Hematopoiesis: decrease in platelets and red blood cells, increase in the number of eosinophils.
5. Other body systems. Oral or genital candidiasis may occur.

If such manifestations occur, you should report them to your doctor. After reducing the dose or stopping the antibiotic, all side effects disappear.

How to take the pills?

The attending physician, depending on the nature of the disease, determines the required dose of antibiotic. Taking Unidox is recommended with meals. Take the tablets with water. If you use the Unidox Solutab dosage form, you can first crush and dissolve the tablets in 20 ml of water.

The following antibiotic treatment regimen is usually used:

1. For adult patients: on the first day, take 200 mg of medication (2 tablets), divided into 2 doses. In the subsequent days of the course of treatment, take 100 mg (1 tablet) of the drug per day. For severe infectious diseases, 200 mg of antibiotic per day is prescribed throughout the entire therapy.
2. For children over 8 years old and weighing more than 50 kg, the treatment regimen is the same as for adults.
3. For children over 8 years old weighing less than 50 kg, the dose is calculated based on body weight. On the first day, take 4 mg of medication per 1 kg of weight. In the subsequent days of treatment, take 2 mg of the drug per 1 kg of body weight (in 2 doses). In severe cases, the dosage of 4 mg/kg is maintained throughout the entire course of treatment.

Treatment with the drug usually lasts from 5 to 10 days. For some diseases, the duration of therapy and dosage of Unidox has its own characteristics:

1. If infected with pyogenic streptococcus, the course of treatment should last at least 10 days.
2. For syphilis, 2 tablets (200 mg per day) are prescribed for 14-28 days.
3. When treating gonorrhea, chlamydia and ureaplasmosis of the genitourinary organs, it is recommended to take 2 tablets per day. The duration of therapy is about 7 days. In case of severe gonococcal infection, the dose can be increased to the maximum allowable - 300-600 mg per day, the course is 5 days.
4. When treating acne on the skin, the drug is taken for a long time, from 6 to 12 weeks at a dosage of 100 mg per day.
5. To treat leptospirosis, the antibiotic is taken at a dosage of 200 mg per day for a week. To prevent this disease, the drug is taken at a dose of 200 mg once a week while staying in areas unfavorable for leptospirosis. Then take another 200 mg before leaving.
6. To prevent malaria, take 100 mg of the medicine 1 day before the trip, and then the same dose daily during the trip. After returning home, antibiotics must be continued at the same dosage for another 4 weeks.
7. 1 hour before a medical abortion, women take 1 Unidox tablet, and immediately after the intervention take 2 more tablets. This helps prevent infection.

It must be remembered that doxycycline greatly increases the skin's sensitivity to ultraviolet radiation. Therefore, during the course of treatment you should avoid tanning or use creams with a high degree of protection.

Compatibility with other medications and alcohol

Some medications may interfere with the absorption of doxycycline. These include antacids, iron supplements, and laxatives with magnesium. Therefore, you need to maintain an interval of 3 hours between taking Unidox and these medications.

It is not advisable to take vitamin A (retinol) during antibiotic treatment. This can cause headaches due to increased intracranial pressure. You should also not combine Unidox treatment with penicillin and cephalosporin antibiotics. These medications will decrease the effects of doxycycline.

Women taking hormonal contraceptives should remember that doxycycline reduces the contraceptive effect of these drugs and increases the likelihood of non-cyclic uterine bleeding.

Patients should know that Unidox and alcohol are incompatible. Drinking alcohol increases the metabolism of the drug, as a result, the concentration of the antibiotic in the blood plasma drops, and the therapeutic effect is reduced to zero. At the same time, a double load falls on the liver, which manifests itself in nausea, vomiting, abdominal pain, diarrhea, and dizziness.

Barbiturates, Carbamazepine, Phenytoin, and Rifampicin can also reduce the therapeutic effect of the antibiotic.

Conditions for dispensing from pharmacies and storage rules

The drug is available with a doctor's prescription. You cannot self-treat with the Unidox antibiotic.

The instructions recommend storing the tablets at a temperature of +15 to +25 degrees. To avoid poisoning, the medicine should be kept in a place where children cannot find it. If the storage rules are followed, the drug is suitable for use for 5 years. After this period, the tablets cannot be taken.

Price of tablets

The price of Unidox in Moscow pharmacies is from 280 to 370 rubles. Currently, you can find on sale mainly Unidox Solutab tablets, which are a soluble form of the drug.

Analogues of the drug

Patients are often interested in analogues of Unidox. You can choose drugs with the same active ingredient - doxycycline. The following medications fall into this category:

• "Doxycycline."
• "Vibramycin".
• "Doxibene".
• "Xedocin."
• "Dovitsin".
• "Doxilan."
• "Monocline".
• "Bassado".

Of these drugs, Doxycycline is the most common analogue of Unidox. Its price is very low - from 12 to 32 rubles.

Can Doxycycline be considered a complete replacement for Unidox Solutab soluble tablets? If we consider the chemical composition of these drugs, they contain different modifications of the same medicinal substance. "Doxycycline" is produced on the basis of hydrochloride, and "Unidox Solutab" is produced on the basis of monohydrate. They have the same therapeutic effect, but there are slight differences:

1. Soluble tablets (solutab) are better absorbed by the body.
2. Solutab tablets have fewer side effects, as they dissolve well and are absorbed in the intestines. Doxycycline begins its action in the stomach, which often causes cramps and pain.
3. "Unidox Solutab" goes through several stages of purification during production and is a safer medicine.

We can conclude that Doxycycline is a cheap analogue of Unidox and is somewhat more difficult to tolerate by the body.

Country of origin

Product group

Antibiotic of the tetracycline group

Release forms

• Tablets 100 mg - 10 pcs per pack.

Description of the dosage form

• Dispersible tablets

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• doxycycline monohydrate, in terms of doxycycline 100 mg Excipients: microcrystalline cellulose, saccharin, hyprolose (low-substituted), hypromellose, colloidal silicon dioxide (anhydrous), magnesium stearate, lactose monohydrate.

Unidox Solutab indications for use

• Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - respiratory tract infections (including pharyngitis, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, pleural empyema); - infections of the ENT organs (including otitis media, sinusitis, tonsillitis); - infections of the genitourinary system (cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orchiepididymitis; endometritis, endocervicitis and salpingoophoritis /as part of combination therapy/); - sexually transmitted infections (urogenital chlamydia, syphilis in patients with penicillin intolerance, uncomplicated gonorrhea /as an alternative therapy/, granuloma inguinale, lymphogranuloma venereum); - infections of the gastrointestinal tract and biliary tract (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, travelers' diarrhea);

Unidox Solutab contraindications

• - severe dysfunction of the liver and/or kidneys; - porphyria; - pregnancy; - lactation period (breastfeeding); - children under 8 years of age; - hypersensitivity to tetracycline antibiotics.

Unidox Solutab dosage

• 100 mg 100 mg

Unidox Solutab side effects

• From the digestive system: anorexia, nausea, vomiting, dysphagia, diarrhea, enterocolitis, pseudomembranous colitis, esophagitis, esophageal ulcer, dark staining of the tongue, liver damage (during long-term use or in patients with renal or hepatic insufficiency), cholestasis. Dermatological reactions: photosensitivity, maculopapular and erythematous rash, exfoliative dermatitis. Allergic reactions: urticaria, angioedema, anaphylactic reactions, exacerbation of systemic lupus erythematosus, pericarditis, a syndrome similar to serum sickness, erythema multiforme. From the hematopoietic system: hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, decreased prothrombin activity. From the endocrine system: in patients receiving doxycycline for a long time, reversible dark brown discoloration of the thyroid tissue is possible. From the side of the central nervous system: benign increase in intracranial pressure (anorexia, vomiting, headache, papilledema), vestibular disorders (dizziness or instability), blurred vision, double vision. From the urinary system: increase in residual urea nitrogen (due to the anti-anabolic effect). From the musculoskeletal system: doxycycline slows down osteogenesis, disrupts the normal development of teeth in children (irreversibly changes the color of teeth, enamel hypoplasia develops).

Drug interactions

Storage conditions

• keep away from children