How to properly administer Polygynax to a girl. Polygynax Virgo - instructions for use, analogs, application, indications, contraindications, action, side effects, dosage, composition

In pediatric gynecology, specialists often encounter various inflammatory ailments. In this case, drugs for treatment must be selected with special care. The drug "Polygynax Virgo" is considered safe and effective for children. The instructions recommend using it for typical gynecological pathologies. Let's take a closer look at the indications for use, composition and reviews of the drug.

Description of the drug

Gynecological diseases in pediatrics are not uncommon. The main causes of such ailments lie in a weak immune system, frequent infectious diseases, and the presence of chronic tonsillitis. For the successful treatment of inflammatory processes, doctors often prescribe the French-made drug Polygynax Virgo. The use of this medication allows you to get rid of unpleasant symptoms quite quickly.

"Polygynax Virgo" is a combination drug that has a versatile therapeutic effect. Belongs to the category of antifungal and antibacterial medications for topical use. The release form and dosage of active substances are specially selected for use in pediatric gynecology.

Compound

What substances provide the therapeutic effect of the drug "Polygynax Virgo"? The composition is described in detail in the instructions with the exact dosage of each component.

The combined drug contains three active components at once, which allow you to influence the problem in a comprehensive manner. Nystatin (at a dosage of 100,000 IU) has antifungal properties. This substance effectively copes with fungal pathogens that affect the mucous membranes. The fungicidal effect extends to yeast-like fungi of the genus Candida and Histoplasma, cryptococci.

Neomycin sulfate (35000IU) is a powerful antibacterial substance. Staphylococci, enterococci, Haemophilus influenzae and Pseudomonas aeruginosa, Klebsiella pneumoniae, Ureplasma, and Corynebacteria exhibit sensitivity to it.

Polymyxin "B" sulfate is another antimicrobial substance that affects gram-negative microorganisms. The drug contains 35,000 IU.

Dimethicone, hydrogenated soybean oil, glycerol, gelatin, tefose 63 are used as excipients.

Release form

The original release form allows the use of Polygynax Virgo in pediatric gynecology. Capsule suppositories have an elongated pear-shaped shape and are intended exclusively for intravaginal administration. Thanks to this, it is possible to influence the inflammatory process directly at the local level and reduce the negative impact of active components on the body as a whole.

The soft capsule contains an oily emulsion. The shell of the candles can be beige or pale pink. They are packaged in cardboard packages of 6 or 12 pieces.

Indications for the use of "Polygynax Virgo"

The use of the drug is justified in the treatment of bacterial and fungal inflammatory processes in gynecological practice. The drug has a pronounced bactericidal and antimycotic effect and therefore effectively fights ailments of this type. The manufacturer recommends the use of intravaginal suppositories in the following cases:

• for vulvovaginitis of fungal and mixed etiology;
• for nonspecific vulvovaginitis in girls and adolescents;
• for cervicovaginitis (inflammation of the cervix and vaginal mucosa);
• for cystitis in acute and chronic form.

The drug quickly eliminates itching and discomfort due to inflammation. The instructions recommend using capsules with Polygynax Virgo emulsion as a preventive measure before an examination to prevent infection and the development of the inflammatory process. Quite often they are prescribed before surgery, cauterization of erosion.

Active antimicrobial and antimycotic components suppress the vital activity of pathogenic organisms at any stage of the disease. In addition, pathogenic agents that are in the dormant stage, but can cause a relapse of the disease at any time, come under attack.

Who is the drug suitable for?

The instructions recommend using "Polygynax Virgo" for the treatment of inflammatory gynecological pathologies in children and adolescents. Before prescribing a medication, it is necessary to undergo an examination by a specialist and undergo laboratory tests that will allow you to accurately determine the type of causative agent of the disease.

Symptoms of the development of vulvovaginitis include the appearance of purulent discharge from the genital tract, burning, itching, redness and inflammation of the genitals. Treatment of the disease in girls should be started immediately to avoid inflammation becoming chronic.

Mode of application

Manipulations for the introduction of suppositories are carried out only after hygiene procedures. It is recommended to use the medicine at night. Before inserting the capsule, the pointed tip must be cut. The emulsion is inserted into the vagina with light pressure, after which the capsule itself is thrown away.

You should use 1 capsule of Polygynax Virgo per day. The price of the medicine depends on the number of suppositories in the package. So, 6 soft candles will cost 390-450 rubles. One package is enough to complete the full course of therapy. If necessary, the doctor may prescribe a second course of treatment with Polygynax Virgo after a certain period of time.

The combination of active ingredients and their dosage in capsules were specially selected for use in pediatric practice. The drug has minimal systemic effects on the body, because the substances are practically not absorbed into the general bloodstream and affect the inflammatory process exclusively at the local level.

In cases where nonspecific vulvovaginitis is detected in girls and adolescents, longer treatment with Polygynax Virgo will be required. In this case, the instructions recommend undergoing 12-day therapy. Do not interrupt treatment when menstruation occurs. Adjusting the dosage of the drug is necessary if the child has problems with kidney function.

Contraindications, side effects

Can the use of Polygynax Virgo capsules cause negative reactions in the body? Analogues of the drug, like the original medicine, cause side effects extremely rarely. They manifest themselves in the form of allergic reactions - itching and redness. To avoid such manifestations, you should first of all become familiar with the contraindications to the use of the combined drug.

Suppositories are not prescribed if the child has hypersensitivity to the active or auxiliary components.

How to replace Polygynax Virgo?

Capsule analogues are usually selected due to the high cost of imported medicine. Terzhinan (France) has a similar composition. The therapeutic effect is provided by components such as ternidazole, nystatin, neomycin sulfate, prednisolone. However, among the contraindications for use, the drug has an age restriction - it is not prescribed to patients under 16 years of age. In this case, preference should be given to Polygynax Virgo capsules. The price of Terzhinan candles is 380-420 rubles (10 pieces). Another popular analogue is Pimafucin suppositories.

Experts characterize the original remedy as safe and effective for various inflammatory processes of the genitals. A replacement should be selected only in cases of intolerance to the components.

Polygynax Virgo is a drug (emulsion) that corresponds to the group of antiseptics and antimicrobials for the treatment of gynecological diseases. This drug is characterized by the following application features:

• Sold only with a doctor's prescription
• During pregnancy: contraindicated
• When breastfeeding: contraindicated

Package

Polygynax Virgo is a local antibacterial and antifungal drug.

Release form and composition

The dosage form of Polygynax Virgo is an emulsion for intravaginal administration in capsules: capsules are soft, oval, with a pointed elongated tip, color from light yellow to light brown; the contents of the capsule are an oil emulsion from light yellow to brown (3 capsules in a blister, 1 or 2 blisters in a cardboard box).

Composition of 1 capsule:

• active ingredients: neomycin sulfate – 35,000 IU, polymyxin B sulfate – 35,000 IU, nystatin – 100,000 IU;
• auxiliary components: hydrogenated soybean oil, dimethicone 1000, Tefoz 63 (esters of palmitic and stearic acids);
• capsule shell: gelatin, glycerol, dimethicone 1000, purified water.

Pharmacological properties

Pharmacodynamics

Polygynax Virgo is developed for use in pediatric gynecology and is a combined drug with antifungal and antibacterial effects.

The drug has bactericidal activity against gram-positive (including corynebacteria, Staphylococcus aureus, etc.) and gram-negative bacteria (including Escherichia coli, Haemophilus influenzae, Enterobacter aerogenes, Enterococcus faecium, Proteus vulgaris, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Klebsiella pneumoniae, ureaplasma urealiticum).

The fungicidal effect of Polygynax Virgo is directed against pathogenic fungal strains, especially yeast-like fungi of the genus Candida albicans (thrush), cryptococci and histoplasmas.

In addition, the drug helps improve trophic processes in the vaginal mucosa.

Intravaginal administration of capsules ensures uniform distribution of active components over the vaginal surface.

Pharmacokinetics

Absorption of Polygynax Virgo into the systemic circulation is insignificant.

Indications for use

According to the instructions, Polygynax Virgo is indicated for use in pediatric gynecology for the treatment of the following diseases:

• vaginitis (nonspecific, fungal, mixed);
• vulvovaginitis;
• cervicovaginitis.

In addition, the drug is used for prophylaxis before surgical operations in the genital area, as well as before intrauterine diagnostic procedures.

Contraindications

A contraindication to the use of Polygynax Virgo for children is increased sensitivity or an allergic reaction to any of the components of the drug.

Instructions for use of Polygynax Virgo: method and dosage

Polygynax Virgo for children is used intravaginally, 1 capsule per day, after the evening toilet, before bedtime. The pointed end of the capsule should be cut and, pressing on the capsule, its contents should be inserted into the vagina. The used capsule must be disposed of.

Both preventive and therapeutic courses of use are 6 days, unless otherwise recommended by a doctor.

If a dose of the drug is missed, treatment is continued according to the same regimen.

Side effects

Allergic reactions may develop.

With long-term use, there is a risk of developing systemic side effects of aminoglycosides, which increase if the patient has renal failure.

Overdose

No cases of overdose have been recorded with intravaginal administration of Polygynax Virgo.

special instructions

During treatment with Polygynax Virgo, you should refrain from using intravaginal tampons. During menstruation, it is recommended to continue using the drug.

For impaired renal function

In patients with renal failure, the dose and duration of treatment should be prescribed individually by the doctor.

Use during pregnancy and lactation

The use of the drug during pregnancy is possible only as prescribed by a doctor. In the event that pregnancy becomes known during treatment with Polygynax Virgo, the decision on further therapy should be made by the attending physician.

The use of the drug during lactation is contraindicated.

Use in childhood

Drug interactions

Spermicides may reduce the effectiveness of Polygynax Virgo, and therefore their combined use is contraindicated.

Analogues

Analogues of Polygynax Virgo are: Dalacin, Clindamycin, Natamycin, Vagitsin, Nystatin, Clindacin, Pimafucin, Sintomycin, Clindes, Milagin, Primafungin, Ecofucin, Neotrizol, Cervugid, Meratin, Terzhinan.

Terms and conditions of storage

Store at temperatures between 15 and 25 °C. Keep away from children.

Shelf life – 18 months.

Conditions for dispensing from pharmacies

Dispensed by prescription.

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1 capsule contains:

active ingredients: neomycin sulfate 35,000 IU, polymyxin B sulfate 35,000 IU, nystatin 100,000 IU

Excipients: Tefoz ® 63, hydrogenated soybean oil, dimethicone 1000;

capsule shell: gelatin, glycerin, dimethicone 1000, purified water.

Dosage form

Vaginal emulsion, in capsules.

Pharmacological group

Antimicrobial and antiseptic agents for use in gynecology. Antibiotics.

ATC code G01A A51.

Indications

Local treatment of vaginitis caused by microorganisms sensitive to the drug, including:

• bacterial vaginitis caused by banal pyogenic microflora;
• recurrent nonspecific vaginitis;
• vaginitis caused by fungi of the genus Candida;
• vaginitis caused by mixed infection.

Contraindications

Hypersensitivity to the components of the drug (or hypersensitivity to this group of drugs).

Directions for use and doses

It is necessary to cut the pointed end of the capsule with scissors. After this, the contents of 1 capsule should be administered intravaginally in the evening before bedtime for 6 days in a row.

Do not stop treatment during menstruation.

Adverse reactions

Local irritation reactions, including redness, swelling, itching of the vaginal mucosa. There may be hypersensitivity in patients to the auxiliary component of the drug soybean oil. Allergic reactions are possible, including anaphylactic shock and urticaria.

Due to the short duration of treatment with the drug, the risk of systemic toxic effects (for example, on the kidneys, hearing organs) is minimal.

Overdose

There are no reports of overdose of Polygynax Virgo.

Use during pregnancy and lactation

The drug is intended for use in pediatric gynecological practice.

Children

A special dosage form - Polygynax Virgo - is used in pediatric practice.

Features of application

Before prescribing the drug, it is necessary to conduct a bacteriological study. To avoid transmission of the disease, the patient must be warned about using separate personal hygiene products (washcloth, towel), and wearing natural cotton underwear.

The dosage form of Polygynax Virgo is intended for use in children.

The ability to influence the reaction rate when driving vehicles or other mechanisms

Does not affect.

Interaction with other drugs and other types of interactions.

There are no data on undesirable effects of interaction of the drug Polygynax Virgo with other drugs.

Pharmacological properties

Pharmacodynamics. The properties of the drug consist of the properties inherent in the individual components. Neomycin sulfate is an aminoglycoside antibiotic that has a bactericidal effect by blocking the function of bacterial ribosomes in a wide range of gram-positive and gram-negative microorganisms: Corynebacterium spp., Staphylococcus spp., Mycobacterium tuberculosis, Enterococcus faecium, Escherichia coli, Enterobacter aerogenes, Haemophilus influenzae, Klebsiella pneumoniae, Proteus vulgaris. Polymyxin B sulfate is a polypeptide antibiotic that acts bactericidal mainly against gram-negative flora, especially Pseudomonas aeruginosa; strains are also sensitive E. coli, Schigellae, Klebsiellae, Pasteurellae, Serratiae, Staphylococcus spp., Enterobacter, Salmonellae, Haemophilus, Bordetella. Polymyxin B disrupts the osmotic resistance of bacterial membranes and is also active against pathogens that are at rest. Nystatin is a polyene antibiotic that acts fungicidal or fungistatic by binding ergosterol to the cytoplasmic membrane of fungi. Is active in relation to Candida spp., Histoplasma spp., Coccidioides spp., Cryptococcus spp., Aspergillus, Blastomyces dermatidis. Resistance to the active ingredients of Polygynax Virgo develops rarely and slowly.

Dimethylpolysiloxane (dimethicone 1000), contained in the drug as an excipient, is an organic compound with a high molecular weight that has enveloping properties, anti-inflammatory, reparative and anti-allergic effects, improves trophic processes in the vaginal mucosa, and also prevents the penetration of the active components of the drug into the mucous membrane .

Pharmacokinetics.

We haven't studied it.

Basic physical and chemical properties

smooth, oval capsules with a pointed, elongated end, pale yellow to beige.

Best before date

1.5 years (18 months).

Do not use after the expiration date stated on the package.

Storage conditions

Store in original packaging at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Package

3 capsules in a blister, 2 blisters in a cardboard box.

Vacation category

On prescription.

Manufacturer

Innotera slush, France / Innotera Chouzy, France.

Location

Rue Rene Chantereau L'Isle Vert, 41150 Chouzy-sur-Cisse, France.

One of the common problems when visiting a pediatric gynecologist is bacterial or fungal vulvovaginitis. In the treatment of such a disease, various means are used, among which Polygynax can be called. How does this French medicine work, is it used in children, and how to administer it correctly to a child?

Release form and composition

Polygynax is presented in two types in pharmacies:

• Vaginal capsules. They are oval in shape and yellowish or beige in color. Inside the capsule there is a yellow-brown semi-liquid mass. This medication is sold in blisters of 6 pieces, and one pack contains 6-12 capsules.
• Emulsion, which is administered intravaginally. This form of the drug is called Polygynax Virgo. The emulsion itself, like the contents of vaginal capsules, is a semi-liquid substance of a yellow-brown hue. It is also placed in a soft oval yellow-brown capsule, but this capsule has an elongated pointed end. The drug Virgo is sold in blisters of 3 pieces, and one pack contains 3-6 capsules.

The action of both drugs is provided by a complex of three active substances:

1. Neomycin. This component in the form of sulfate is presented in 1 capsule with a dosage of 35 thousand IU.
2. Nystatin. The dosage of this ingredient in each capsule of Polygynax and Virgo is 100,000 IU
3. Polymyxin B. The amount of this substance in the form of sulfate per 1 capsule is 35,000 IU.

Additionally, the capsules include soybean oil, dimethicone, gelatin and some other substances.

Operating principle

Due to the presence of antibacterial and antifungal components in the composition, Polygynax effectively destroys various types of microorganisms, including candida. In addition, the medication has a positive effect on the trophic processes occurring in the mucous membrane of the genital tract. After entering the vagina the medicine acts only locally and is almost not absorbed.

Indications

Polygynax and the drug Virgo are used for gynecological diseases caused by pathogens sensitive to the drug. The drug is in demand in the treatment of:

• fungal vaginitis;
• nonspecific vaginitis;
• vaginitis caused by several microorganisms;
• vulvovaginitis;
• cervicovaginitis.

In addition, Polygynax is prescribed before surgery or a diagnostic procedure in the vagina or cervix.

At what age is it prescribed?

Polygynax capsules are usually not used in children, since such a medication must be inserted deeply into the vagina, which is often impossible in girls.

Polygynax Virgo is called the pediatric form, since this medicine can be used in girls and adolescents.

It is not contraindicated at any age, so it is prescribed both to children in the first years of life (for example, an 11-month-old baby) and to girls of preschool or school age.

Contraindications

The medication should not be used only in patients with hypersensitivity to neomycin, nystatin, polymyxin B or any auxiliary component of the drug.

Side effects

The use of Polygynax may cause an allergic reaction, as well as a burning or itching sensation.

Instructions for use

The drug Polygynax Virgo is used at night after the evening toilet. The pointed tip of the capsule is cut off and, having inserted the cut capsule shallowly into the vagina, lightly press on it so that the emulsion gets onto the mucous membrane. After this, the capsule itself is thrown away.

A single dose of the medicine is the contents of one capsule. The duration of use is usually 6 days.

If the next dose is accidentally missed, you do not need to use 2 capsules the next day, but simply continue treatment at the dosage prescribed by your doctor.

Terms of sale and storage

To purchase Polygynax Virgo at a pharmacy, you need to get a prescription from a doctor.

The average price of 6 capsules with emulsion is 500 rubles. It is recommended to store the drug at home at room temperature. The shelf life of the medicine is 2 years.

Emulsion for intravaginal administration in capsules - 1 capsule:

• active substance: neomycin sulfate - 35,000 IU; polymyxin B sulfate - 35000 IU; nystatin - 100,000 IU;
• excipients: Tefoz 63® - 143.87 mg; hydrogenated soybean oil - 34.56 mg; dimethicone 1000 - up to 2730 mg;
• capsule shell: gelatin - 768 mg; glycerol - 386 mg; dimethicone 1000 - 175 mg; water - q.s.

Emulsion for intravaginal administration in capsules. 3 caps. in PVC/PVDC aluminum blisters. 1 or 2 bl. in a cardboard box.

Description of the dosage form

Emulsion for intravaginal administration in capsules from light yellow to light brown, soft, oval in shape with a pointed, elongated end; the contents of the capsules are an oily emulsion from light yellow to brown.

Characteristic

Capsules are ovoid in shape with a pointed elongated end, light beige in color, smooth, opaque, average length 5.8 cm, width at the narrow part 6 mm, at the wide part - 15 mm, containing a homogeneous oily creamy mass.

pharmachologic effect

Antibacterial, antifungal local.

Pharmacokinetics

When injected into the vagina, it is distributed over the walls and envelops them. Does not penetrate mucous membranes.

Pharmacodynamics

A combined drug whose effect is determined by its constituent components. Has antibacterial, bactericidal and antifungal effects.

Neomycin and polymyxin B are active against many gram-negative and gram-positive microorganisms; Streptococcus spp. and anaerobic bacteria are insensitive to these antibiotics.

Nystatin has a fungicidal effect against fungi of the genus Candida.

Indications for use of Polygynax virgo

• cervicitis;
• vaginitis (bacterial, fungal or mixed origin);
• preoperative prevention of infectious complications during gynecological interventions, before childbirth, when installing a contraceptive device, during intraurethral examinations.

Polygynax Virgo contraindications

• hypersensitivity;
• pregnancy;
• lactation period.

Use of Polygynax Virgo during pregnancy and lactation

Contraindications: pregnancy; lactation period.

Side effects of Polygynax virgo

Allergic contact eczema; with long-term use - ototoxicity, nephrotoxicity.

Dosage

Intravaginally. 1 capsule, after evening toilet, before bed. By cutting the pointed end and lightly pressing on the capsule, the contents of the capsule are inserted into the vagina. After introducing the drug into the vagina, the capsule is thrown away. The course of treatment is 6 days.

For the purpose of prevention, the drug is used for 6 days.

If a drug dose is missed, treatment should be resumed at the usual dose.

Precautionary measures

Before using the drug, it is necessary to first take a smear and conduct a bacteriological analysis.