The effect of alcohol on the central nervous system. The autonomic nervous system regulates the functioning of all human organs

One of the most important systems of the human body is the nervous system. It is she who coordinates the work of all other organs and systems. Thanks to her, we breathe, move, eat. Our emotions, sequence of actions and much more depend on it. And throughout our lives we consciously and unconsciously cause significant damage to it. What harms her the most?

How our nervous system works

Let's start with the fact that the nervous system has a complex structure; it consists of the following structures and sections.

  • Central nervous system - brain and spinal cord.
  • Peripheral nervous system - nerve roots, nodes (ganglia, plexuses, cranial and spinal nerves, etc.).
  • Autonomic (or autonomic) nervous system. It is divided into sympathetic and parasympathetic parts, which connect to all organs and muscles and regulate processes in them that do not depend on our will. For proper functioning of organs, the required level of excitability must be observed in both parts of the autonomic nervous system.

How does the nervous system “give commands”? With the help of its cells, neurons and their processes. The processes go into the muscles or to the processes of other nerve cells, forming a chain of nerve signal transmission. Thus, a variety of information passes from the brain to the muscles, organs and tissues, as well as return information from the senses (touch, vision, smell, etc.) to the brain. Many chemicals take part in this complex work, the main ones of which are various neurotransmitters and hormones, such as acetylcholine, norepinephrine, dopamine and many others. The membrane of nerve cells contains receptors that interact only with certain neurotransmitters and hormones needed by the cell according to the key-lock principle. In addition, in each nerve cell, the decomposition of hundreds of different chemical compounds occurs every minute, resulting in a flow of electrical impulses. These impulses are transmitted along a chain of neurons until they reach the target - an organ, muscle, vessel, etc.

This whole complex system is quite strong and should work properly throughout its life. It would have been so if it had not been influenced by a variety of negative factors.

What spoils our nervous system


Bad habits and their destructive power

Smoking, alcohol and drugs are the most sworn enemies of our health. And this is especially true for the cardiovascular and nervous systems.

Alcohol

Of the hundreds of harmful substances contained in cigarette smoke, nicotine is the most dangerous for the human nervous system. It has a particularly detrimental effect on the autonomic nervous system, disrupting its coordination work in regulating the functioning of internal organs and muscles. Thus, diseases of the cardiovascular system, digestive organs and other important organs and systems largely begin as a result of disruptions in the functioning of the autonomic nervous system. Higher nervous activity also worsens as a result of nicotine poisoning: memory deteriorates, memory is impaired, neurasthenia occurs, and even epileptic seizures occur. The smoker’s mistake is that he tries to “take it off” by increasing the number of cigarettes, and this only leads to increased fatigue, headaches, irritability, persistent insomnia, trembling limbs, and dizziness. If you smoke a large number of cigarettes in a short time, acute nicotine poisoning can occur with a fatal outcome.

Drugs

The effects of drugs are detrimental to all three parts of the nervous system. The psyche gradually collapses, a person cannot think logically, he develops persistent depression, and there are hallucinations even when not taking drugs. He becomes aggressive, anxious, suspicious, and experiences constant fear. Needless to say, how does a drug addict’s life usually end?..

The nervous system and psyche, health and appearance of a person are closely interconnected.

Some experts emphasize the benefits of receiving small amounts of sunlight all year round and believe that a person should always be slightly tanned.

Many skin diseases arise from nerves - they are caused by stress, nervous breakdowns, and prolonged overstrain of the nervous system. People with a trained nervous system, a stable neuropsychic state, those who know how to control themselves, and optimists are less susceptible to them. Mental experiences, especially negative emotions - anger and hatred, greed and envy, fear and despondency, sadness, melancholy, dissatisfaction, suspiciousness and intolerance accelerate functional disorders of the nervous system and metabolism, leading to a decrease in the body's resistance.

Properties such as mental balance, cheerfulness, goodwill, positive emotions such as joy, pleasure, delight have a beneficial effect on the nervous system, increase vitality, and relieve fatigue.

To the Council of Doctors of Antiquity " eradicate all annoyances from your heart" is worth following for all of us. It is known that negative emotions sometimes lead to more profound pathological changes in the human body than the effects of physical factors. Under the influence of negative emotional stimuli, temporary functional disorders occur in the cerebral cortex, expressed in the appearance of stagnant foci of excitation that do not find release during the process of inhibition. Frequent mental trauma, especially against the background of mental and physical stress, leads to wear and tear of the nervous system and deterioration of tissue nutrition.

The nervous system and psyche, being in close relationship with the skin, have a direct impact on it. A good mood, joy, and vigor have a positive effect on blood circulation and improve the functioning of the skin. On the contrary, bad mood, melancholy, anger, displeasure inhibit the stimulating functions of the skin, impulses from the brain lead to vasospasm and insufficient nutrition of the skin. The sweat and sebaceous glands weaken their activity, the skin takes on a dry, gray, unhealthy appearance.

The state of the nervous system and psyche is also reflected in the state of the hair, which is an appendage of the skin. There are often cases when, after severe mental trauma, patchy hair loss or pigmentation disorders - graying - appear, and in case of a disease of the nervous system - in addition, exhaustion and fragility.

This influence of the nervous system and psyche on the skin is used in medicine to treat, through verbal suggestion (hypnosis), a number of skin diseases and their manifestations, for example warts, itchy skin, lichen planus, etc.

It is very important to train and educate the nervous system from childhood in order to form it strong, balanced, mobile, capable of withstanding prolonged and strong stimulation and overcoming various, sometimes very difficult, trials of life. I. P. Pavlov noted that the nervous system has significant plasticity and pliability to training - these properties should be used for its hardening, education, and, if necessary, for re-education.

Sufficient, complete, deep sleep helps keep the nervous system in good shape.

Ethanol, once in the human body, appears in the bloodstream literally after 1.5–2 minutes. Intoxication, which immediately follows relaxation with strong drinks, is a consequence of intoxication of brain structures. Not only the brain is directly affected by the toxic metabolites of alcohol; the central nervous system also suffers from intoxication.

Toxic damage to the nervous system is clearly felt by a tipsy person. This manifests itself in the form of visual impairment, decreased coordination of movements, foggy consciousness, confusion of thinking, disinhibition and the inability to adequately perceive surrounding events. What other consequences does the influence of alcohol have on the human nervous system and what are the consequences?

Alcohol has an extremely negative effect on the human nervous and brain systems.

Alcohol, through the bloodstream, actively and quickly spreads throughout the body, affecting the functioning of almost all internal systems of the body. The very first to fall under the deadly poisonous blow are the brain cells, which leads to tangible changes regarding reflex-conditional functions.

It has been established that about 80% of ethyl alcohol accumulates in the gray brain matter, but the white structure “takes” about 75% of ethanol.

Due to the ongoing disturbances in the excitation departments, which occur with the simultaneous stopping of the nervous processes occurring in the brain, the intoxicated person feels a certain stiffness when moving. There is a loss of ability to navigate in the surrounding space.

Some time after drinking alcohol, the frontal lobes of the brain become intoxicated (they respond to the manifestation of emotions). This is reflected in the behavior of the drinker - the person feels joy and a general excited, elated state. Soon, overexcitation of higher nervous processes, coupled with reduced functioning of the structures responsible for inhibition, leads to a loss of control over lower brain areas - this manifests itself in the loss of ethical and moral behavioral foundations characteristic of a sober person.

Alcohol has an increasingly powerful effect on nerve cells, and its destructive power increases with each glass taken. Gradually, the work of the higher centers of the brain completely stops. In this connection, control over behavioral reactions and the work of internal organs as a whole is transferred to the lower parts of the brain. At this stage of intoxication, further disorders are formed - such as decreased vision, problems with the vestibular apparatus.

Initially, alcohol has a liberating effect

The functioning of parts of the brain and central nervous system when drinking alcoholic beverages is disrupted in any case, regardless of the dose and regularity of alcohol consumption.

Damage to the nervous system

Considering the nuances of this process, and finding out how alcohol affects the nervous system, you can notice that the brightness and completeness of the emerging problems directly depend on the concentration of ethanol metabolites in the blood plasma e. Doctors have determined the following indicators of the degree of damage to certain areas of the brain (where % is the dose blood ethanol concentration):

  1. Relief of the work of the cerebral cortex: 0.04–0.05%.
  2. Damage to deep areas of the brain: 0.1%.
  3. Destabilization of the functioning of the frontal lobes (structures responsible for behavioral and emotional reactions): 0.2%.
  4. Alcoholic stupor: 0.3%.
  5. Loss of consciousness (blackout): 0.4%.
  6. Fatal level (often results in human death): 0.6–0.7%.

First level

The feeling of a pleasant feeling of euphoria, slight excitement, relaxation that occurs with a light level of drunkenness (0.04-0.05% alcohol content) occurs due to problems in the functioning of the cerebral cortex. The impossibility of continuing the normal operation of these areas is based on their intoxication due to the toxic effects of ethanol.

At this stage, the intoxicated person becomes inaccessible to such manifestations of brain activity as:

  • logical thinking;
  • adequacy of understanding of the situation;
  • self-control and behavioral responses;
  • natural assessment of current events in the surrounding reality.

Second level

Degeneration of the nervous system caused by alcohol leads to the fact that the cerebral cortex gradually turns off, and control of the body is transferred to other parts. Continued consumption of alcohol leads to an increase in its concentration in the blood. Moreover, when the level of ethanol increases by only 1/10 percent, damage occurs to the brain areas that monitor motor skills and human movement (gait becomes unstable and shaky, falls become frequent).

Ethanol is an extremely toxic substance for the functioning of brain structures

At this stage of intoxication, the following symptoms are characteristic of a person:

  • mood swings (sharp change from joy to aggression, from fun to depression);
  • loss of speech functions, awareness and consistency of conversation disappears.

Third level

As ethanol metabolites increasingly penetrate into the brain, visual functions are also damaged. And intoxication at an alcohol concentration of 0.2% already provokes deep disturbances in the functioning of the frontal brain regions, which manifests itself in deliberately defiant and aggressive behavior.

Fourth level

With continued active consumption of alcohol, a person is faced with such a manifestation as “alcoholic stupor” (dullness). At this stage, there is a complete loss of the ability to analyze information coming from outside (at an ethanol concentration of 0.3%). An intoxicated person stops responding to sound/auditory stimuli.

Fifth level

Degeneration of the nervous system caused by alcohol continues until the person simply switches off. This often occurs when blood ethanol levels are around 0.4%. This state of alcoholic stupor is based on the simultaneous loss of sensitivity and loss of unconditioned reflexes (stereotypical innate reactions to external stimuli). At this stage of intoxication, spontaneous bowel and bladder emptying often occurs.

How does alcohol affect the human brain?

Sixth level

The concentration of ethanol in the blood at a level of 0.6-0.7% is already considered deadly. In frequent cases, such intoxication ends in the death of a person - respiratory arrest occurs due to complete damage to the central nervous system.

For a strong adult, a lethal dose is a liter of strong alcohol taken at one time. For teenagers, this dose is much smaller and amounts to only 200–300 g of alcohol.

Consequences of alcohol intoxication for the central nervous system

Recovery of the nervous system after alcohol takes quite a long time. On average, it takes about 2-3 weeks for a person to return to their original (healthy and sober) norm. Therefore, if alcohol consumption occurs on a regular basis (even a couple of times a month), the nervous system, without having time to fully recover, is subject to chronic poisoning.

This development of events becomes the main reason for the formation of a number of complex and severe pathologies in the individual. Constant ethanol intoxication of the brain and nervous system provokes the appearance of diseases such as:

  • metal-alcohol psychosis;
  • Wernicke-Korsakoff disease;
  • hemorrhagic polyencephalitis;
  • alcoholic encephalopathy;
  • myelopathy (alcoholic polyneuritis).

Metal-alcohol psychosis (or delirium delirium)

Popularly, this disease is often referred to as “squirrel” or “delirium tremens.” Most often observed in patients with stages 2 and 3 of chronic alcoholism. This pathology is formed against the background of a forced (abrupt) abolition of the consumption of already habitual ethanol. The condition is accompanied by a number of characteristic symptoms:

  • blood pressure surges;
  • tachycardia;
  • insomnia;
  • tremor of the limbs;
  • disturbances of consciousness;
  • convulsive manifestations;
  • increased levels of anxiety and restlessness;
  • hallucinations (visual, tactile and auditory).

A patient in this state becomes dangerous not only to himself, but also to others. The patient needs urgent hospitalization and immediate medical care. With timely treatment, there is a possibility of complete cure (with residual manifestations). Otherwise, there is a risk of human death.

Alcohol delirium is one of the serious complications of alcoholism

Wernicke-Korsakoff syndrome

This pathology is a complex of various neuropsychiatric disorders formed on the basis of chronic deficiency of thiamine (vitamin B1). This condition develops with prolonged, constant consumption of alcohol. Pathology manifests itself with the following symptoms:

  • hallucinations;
  • ocular paralysis;
  • heartburn and flatulence;
  • delirium;
  • severe headaches;
  • memory loss (amnesia);
  • movement disorders;
  • confusion (confabulation);
  • motor and nervous overexcitation;
  • nausea, leading to profuse vomiting;
  • nystagmus (eyeball trembling syndrome);
  • autonomic disorders: redness of the skin, hot flashes and chills, increased sweating.

This pathology most clearly manifests itself against the background of various memory problems. The patient perfectly remembers the information that was received before the development of the disease. And he does not remember at all the events that occur during the drinking process. This pathology is extremely difficult to treat and often patients receive a disability group, and already at the age of 35-40 years.

Hemorrhagic polyencephalitis

A severe disease that develops due to inflammatory and infectious damage to the gray matter of the brain. In some types of pathology, selective destruction of individual brain systems occurs. This disease begins with symptoms characteristic of a harmless cold:

  • confusion of speech;
  • unsteadiness of gait due to general weakness;
  • slight increase in temperature;
  • constant lethargy, high degree of fatigue;
  • complete disorientation in the surrounding space.

This syndrome develops rapidly and progresses rapidly. At the last stage of the disease, the patient is already unconscious. This pathology is fatal and incurable.

Alcoholic encephalopathy

A disease that develops against the backdrop of global destruction of brain neurons due to constant consumption of alcoholic beverages. Most often, the syndrome develops during the transition of alcoholism from stage 2 to stage 3. Against the background of such a disease, the patient experiences irreversible degradation, all body functions are gradually reduced to rudimentary (primitive) needs.

Alcoholic encephalopathy is a deadly complication of alcoholism

To develop a history of alcoholic encephalopathy, a person must drink alcohol continuously for 7–20 years. But doctors also noted the early onset of the disease.

This pathology is one of the most severe syndromes. Death occurs in 40–70% of cases. With survival, the alcoholic acquires various mental disorders and severe dementia. Treatment of this disease is carried out exclusively within the walls of a drug treatment clinic.

Myelopathy (or alcoholic polyneuritis)

This syndrome develops as a result of constant falling and subsequent trauma to the spine, neck and face. These injuries very often happen to people who are intoxicated. Ischemic damage to the spinal cord is also involved in the development of the disease. The most common symptoms include the following:

  • tingling sensations in the arms and legs;
  • pain in the lumbar region;
  • disturbances in the blood supply to the tissues of the extremities.

The disease progresses rapidly and in the final stages leads to complete or partial paralysis. The disease is difficult to treat, especially in the presence of chronic alcoholism.

Let's summarize

The legendary scientist Pavlov scientifically proved that even drinking 30–40 g of alcohol inevitably affects the state of the brain and causes disturbances in the functioning of the nervous system. Brain structures, even after apparent sobering up, continue to be under the harmful effects of ethanol for another 3–4 weeks. Everyone should know about this and all the dire consequences, and especially those people who cannot rest and relax without a glass of strong drink.

In contact with

The human nervous system is a complex structure that ensures the proper functioning of the entire organism. Its main function is to receive and process information coming from the outside world and from inside the body, transmitting information about the state of the body to the brain, coordinating voluntary movements of the body, regulating its involuntary functions - breathing, digestion, heartbeat, maintaining body temperature and others. Considering all this, one can imagine how much nicotine and smoking affect the human nervous system.

Anatomically, the human nervous system is divided into the central and peripheral nervous systems - the CNS and the PNS. The central nervous system is a tandem of the brain and spinal cord. The nerve centers contained in the cerebral hemispheres constitute the intellectual basis of a person, provide his personality, consciousness, and understanding. The PNS provides mutual communication between the central nervous system and all organs and systems of the body.

Involuntary functions of the body are controlled by the autonomic nervous system, its structures are located in both the central nervous system and the PNS.

Nicotine and the nervous system

Nicotine is a neurotoxic poison that disrupts the harmonious flow of electrochemical processes in the nervous system and causes the death of neurons. When tobacco addiction occurs, the body becomes accustomed to nicotine.

Initially, nicotine has a stimulating effect on the nervous system, but soon this effect is replaced by depression due to vasoconstriction. During smoking, nicotine becomes a kind of stimulant for the brain, accelerating the conduction of nerve impulses, but then brain processes are greatly inhibited, and the brain’s need for rest is triggered. As you get used to it, the brain itself begins to demand a “dose”, not wanting to work independently, without doping. If it is impossible to smoke, a person experiences anxiety, severe irritability, and lack of attentiveness and concentration.

People who smoke are more likely to experience nervous system fatigue and neurasthenia. A vicious circle is formed: a smoker who works a lot begins to smoke more and more often to fuel the body, and gets even more overworked. Such people may experience memory impairment, sleep disturbances, headaches, frequent mood swings, and decreased performance. Neuritis, radiculitis, polyneuritis - these diseases of the PNS are also common among “hard-core” smokers.

Smoking also has a detrimental effect on the autonomic nervous system, impairing the functioning of internal organs - the activity of the cardiovascular system is disrupted, and the functioning of the digestive organs is disrupted.

The sense organs also receive their “portion” of nicotine influence. With prolonged excessive smoking, disorders such as decreased visual acuity, impaired hearing, taste, and smell are possible.

However, according to recent studies conducted in the USA, it has been proven that nicotine stimulates cognitive abilities. Also, do not confuse the harm of smoking with the effect of pure nicotine.

A person’s intellectual activity suffers from the effects of nicotine; without a cigarette, many become unable to cope with mental tasks, memory decreases, and logical thinking weakens. Acting on the central nervous system like a drug, nicotine makes a person weak-willed and completely dependent on a bad habit.

How to protect your nervous system from the effects of nicotine

It is necessary to move a lot, muscle activity has a beneficial effect on both brain function and conductivity in nerve fibers, in addition, improved blood circulation will have a positive effect on the nervous system.

Intellectual activity involves all components of the nervous system, so solve crosswords, read more, and compose handwritten texts.

Eat right so that your body receives all the necessary minerals and trace elements.

And, of course, stop smoking. Remember that the proper functioning of the body, and, accordingly, a high-quality and fulfilling life is impossible if the functioning of the nervous system is disrupted.

DO YOU WANT TO QUIT SMOKING?


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Alcohol enters the bloodstream from the stomach in just two minutes. Drinking alcoholic beverages leads to intoxication, the symptoms of which are caused by brain intoxication.

First of all, the nervous system is affected by alcohol, which is clearly illustrated by disturbances in speech, vision, and coordination of movement. Foggy consciousness, confusion of thoughts, inability to adequately assess the situation, subsequent severe headache - these are just some of the symptoms of brain poisoning with alcohol.

According to recent studies, the gray matter of the brain is most affected by alcohol.

Data from clinical studies have shown that 80% of ethanol is contained in the gray matter, while the white matter of the brain accumulates 74% of the toxic substance.

How alcohol affects the human nervous system

The blood delivers ethanol throughout the body and the cells of the cerebral cortex are the first to be affected. As a result, changes occur in conditioned reflex functions. A person becomes constrained, unable to navigate in space due to disturbances in the functions of excitation and inhibition of nervous processes.

The frontal lobes, which cause emotional manifestations, are next to be hit by alcohol intoxication. This explains the initial joy and excited state of the participants in the feast. Excitation of nervous processes against the background of reduced inhibition function leads to loss of control over the lower parts of the brain. A person loses his inherent ethical standards of behavior.

Each subsequent glass of alcohol increasingly constrains the activity of higher nerve centers. Responsibility for the body and behavior is completely transferred to the responsibility of the lower parts of the brain. At this stage of intoxication, disturbances in the activity of the vestibular apparatus and organs of vision are noted.

The functions of the nervous system are affected with every alcohol intake, whether episodic or regular. The severity of damage to the nervous system by alcohol

The degree and depth of dysfunction is directly proportional to the amount of ethyl alcohol in the blood plasma. Drinking alcoholic beverages has specific consequences:

  • 0.04-0.05% – the cerebral cortex is switched off;
  • 0.1% – depression of the deep parts of the brain;
  • 0.2% – disrupts the functioning of the frontal lobes responsible for emotions;
  • 0.3% – alcoholic stupor occurs;
  • 0.4% – leads to loss of consciousness;
  • 0.6-0.7% is a lethal level, often resulting in death.

A pleasant feeling of slight intoxication, corresponding to 0.04-0.05% ethanol in the blood, occurs as a result of shutting down the cortex of both hemispheres of the cerebral cortex. Alcohol intoxication and oxygen starvation of cells leads to the inability to perform their functions.

Logical thinking and an adequate assessment of one’s own condition and the surrounding world become inaccessible. The cerebral cortex turns off and delegates its functions to other parts.

Each subsequent dose of alcohol increases concentration and already at one tenth of a percent the functions of the departments that determine motor skills and coordination of movements are inhibited. The gait of a drunken person becomes shaky and unstable. At this stage, falls due to loss of balance are common.

Characterized by unmotivated joy, anger, and despondency. Reaction speed slows down, speech loses consistency. Alcohol penetrates deeper into the brain and reaches the optic and auditory nerves, which leads to hearing and vision impairment. 0.2% ethanol in the blood is characterized by aggressive defiant behavior as a result of deep intoxication of the frontal lobes of the brain.

Further intake of alcohol-containing drinks leads to so-called stupor. A person loses the ability to analyze incoming information when the blood alcohol level is 0.3%. The individual also ignores visual and audio stimuli.

Fans of feasts often pass out at the most inopportune moment, when the blood alcohol level reaches 0.4%. Loss of consciousness is accompanied by a lack of conditioned and unconditioned reflexes and tactile sensitivity.

A very drunk person can burn to death without waking up.

Spontaneous emptying of the bladder often occurs.

Higher concentrations of alcohol are considered lethal and often result in death. Damage to the nervous system by alcohol leads to respiratory arrest at an ethanol level of 0.6-0.7%. The nervous system responsible for lung functions is inhibited.

The lethal dose for an adult is one liter of vodka. For children under 16 years of age, this dose is only 200-300 grams.

Alcohol-related diseases of the nervous system

The brain and nervous system take a very long time to recover from alcohol intoxication. This process usually takes two to three weeks. By drinking only twice a month, a person exposes his nervous system to constant alcohol poisoning. After a short time, the drinker develops diseases of the nervous system and brain caused by constant ethanol intoxication.

By drinking just twice a month it is easy to get the following diagnoses:

  • Alcoholic encephalopathy
  • Hemorrhagic polyencephalitis

Alcoholic encephalopathy

Alcoholic encephalopathy is the name given to regular toxic damage to the brain by alcohol.

As a result of alcoholic encephalopathy, unmotivated acute psychoses and irreversible personality degradation occur. Human functions are reduced to primitive, rudimentary needs. Psychoses are accompanied by delusions of persecution. The person is considered dangerous to himself and others.


Korsakov's syndrome is characterized by short-term memory impairment. The person clearly remembers the information received before the onset of the disease and does not completely remember the events of the last days. Such people often cannot answer where they were an hour or a day ago. Often people suffering from Wernicke-Korsakoff syndrome become completely disabled at the age of 40.


Alcoholic polyneuritis, myelopathy

Alcoholic polyneuritis occurs when alcohol intoxication leads to damage to the peripheral nerves of the spine and limbs. Characteristic symptoms are frequent pain in the lumbar region, poor circulation in the extremities, tingling in the legs or arms. In severe cases, the progressive disease leads to complete or partial paralysis.

A dangerous disease begins with symptoms similar to the flu or acute respiratory infections. Fever, unsteady gait, spatial disorientation, constant fatigue and confusion of speech may not cause alarm. At the last stage of the disease, a person loses consciousness, and bedsores quickly appear on his body. The disease leads to inevitable death.

Alcoholic delirium is commonly called delirium tremens or “squirrel”. The first symptoms of a dangerous condition are causeless anxiety, insomnia, and nightmares. Soon the patient begins to become delirious in reality and is tormented by auditory and visual hallucinations. The patient is capable of harming himself and others without receiving immediate medical attention.

The great Russian scientist I. Pavlov experimentally proved that regular consumption of small doses of alcohol leads to impaired functional reflexes. Consuming 30-40 grams of ethyl alcohol leads to serious disorders of the nervous system.

The brain continues to be under the influence of alcohol for three weeks after the last dose, a famous researcher has proven.

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